An Efficient Synthesis of the C1-C9 Segment of Dictyostatin

Julia Jägel; Martin E. Maier

doi:10.1055/s-2006-932497

LETTER

An Efficient Synthesis of the C1-C9 Segment of Dictyostatin

Julia Jägel, Martin E. Maier*
Institut für Organische Chemie, Universität Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany
Fax: +49(7071)295137; e-Mail: martin.e.maier@uni-tuebingen.de;

Abstract

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Abstract

A tandem strategy consisting of a Marshall reaction of aldehyde 3 with the mesylate 4 followed by hydrometalation of the resulting homopropargylic alcohol derivative 6 and cross-coupling with iodoacrylate 8 led to the dienoate 9.

Key words

cross-coupling - organometallic reagents - stereoselective synthesis - tandem reactions

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References

References and Notes

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